| Atlanta (Georgia) to Key Largo | 643.74 mi (1,035.99 km) |
| Houston (Texas) to Key Largo | 972.17 mi (1,564.56 km) |
| Washington (District of Columbia) to Key Largo | 972.61 mi (1,565.26 km) |
| Baltimore (Maryland) to Key Largo | 1,004.48 mi (1,616.56 km) |
| Philadelphia (Pennsylvania) to Key Largo | 1,072.85 mi (1,726.59 km) |
| St. Louis (Missouri) to Key Largo | 1,095.92 mi (1,763.72 km) |
| Dallas (Texas) to Key Largo | 1,119.88 mi (1,802.27 km) |
| Brooklyn (New York) to Key Largo | 1,135.62 mi (1,827.60 km) |
| New York (New York) to Key Largo | 1,138.93 mi (1,832.94 km) |
| Queens (New York) to Key Largo | 1,144.93 mi (1,842.58 km) |
| Detroit (Michigan) to Key Largo | 1,202.42 mi (1,935.10 km) |
| Chicago (Illinois) to Key Largo | 1,227.43 mi (1,975.36 km) |
| Boston (Massachusetts) to Key Largo | 1,301.44 mi (2,094.47 km) |
| Minneapolis (Minnesota) to Key Largo | 1,547.35 mi (2,490.21 km) |
| Denver (Colorado) to Key Largo | 1,739.07 mi (2,798.76 km) |
| Phoenix (Arizona) to Key Largo | 1,986.17 mi (3,196.43 km) |
| Las Vegas (Nevada) to Key Largo | 2,194.48 mi (3,531.67 km) |
| San Diego (California) to Key Largo | 2,269.85 mi (3,652.96 km) |
| Riverside (California) to Key Largo | 2,291.73 mi (3,688.18 km) |
| Los Angeles (California) to Key Largo | 2,350.53 mi (3,782.82 km) |
| Tampa (Florida) to Key Largo | 234.85 mi (377.96 km) |
| San Francisco (California) to Key Largo | 2,602.07 mi (4,187.62 km) |
| Portland (Oregon) to Key Largo | 2,723.54 mi (4,383.11 km) |
| Seattle (Washington) to Key Largo | 2,753.14 mi (4,430.75 km) |
| Miami (Florida) to Key Largo | 47.42 mi (76.31 km) |