| Wylie to Southchase (Florida) | 953.30 mi (1,534.19 km) |
| Wylie to Southern Pines (North Carolina) | 988.88 mi (1,591.45 km) |
| Wylie to Southfield (Michigan) | 972.41 mi (1,564.94 km) |
| Wylie to Southgate (Michigan) | 963.26 mi (1,550.22 km) |
| Wylie to Southlake (Texas) | 37.18 mi (59.84 km) |
| Wylie to Spanaway (Washington) | 1,666.62 mi (2,682.17 km) |
| Wylie to Spanish Fork (Utah) | 969.21 mi (1,559.79 km) |
| Wylie to Spanish Lake (Missouri) | 531.29 mi (855.02 km) |
| Wylie to Spanish Springs (Nevada) | 1,362.58 mi (2,192.87 km) |
| Wylie to Sparks (Nevada) | 1,363.80 mi (2,194.82 km) |
| Wylie to Spartanburg (South Carolina) | 845.42 mi (1,360.58 km) |
| Wylie to Spearfish (South Dakota) | 882.85 mi (1,420.82 km) |
| Wylie to Speedway (Indiana) | 736.64 mi (1,185.51 km) |
| Wylie to Spencer (Iowa) | 702.46 mi (1,130.51 km) |
| Wylie to Spokane (Washington) | 1,486.04 mi (2,391.55 km) |
