| Wylie to Scottsbluff (Nebraska) | 724.64 mi (1,166.19 km) |
| Wylie to Scottsboro (Alabama) | 610.57 mi (982.62 km) |
| Wylie to Scottsdale (Arizona) | 886.08 mi (1,426.01 km) |
| Wylie to Scranton (Pennsylvania) | 1,280.11 mi (2,060.15 km) |
| Wylie to Seabrook (Maryland) | 1,170.43 mi (1,883.62 km) |
| Wylie to Seabrook (Texas) | 254.85 mi (410.13 km) |
| Wylie to Seaford (New York) | 1,372.61 mi (2,209.00 km) |
| Wylie to Seagoville (Texas) | 26.53 mi (42.70 km) |
| Wylie to Seal Beach (California) | 1,242.16 mi (1,999.06 km) |
| Wylie to Searcy (Arkansas) | 312.96 mi (503.65 km) |
| Wylie to Seaside (California) | 1,451.99 mi (2,336.76 km) |
| Wylie to SeaTac (Washington) | 1,672.18 mi (2,691.12 km) |
| Wylie to Seattle (Washington) | 1,678.86 mi (2,701.87 km) |
| Wylie to Sebastian (Florida) | 1,020.70 mi (1,642.66 km) |
| Wylie to Sebring (Florida) | 976.34 mi (1,571.27 km) |
