| Wyandotte to Southchase (Florida) | 960.81 mi (1,546.27 km) |
| Wyandotte to Southern Pines (North Carolina) | 525.30 mi (845.38 km) |
| Wyandotte to Southfield (Michigan) | 19.09 mi (30.72 km) |
| Wyandotte to Southgate (Michigan) | 2.59 mi (4.17 km) |
| Wyandotte to Southlake (Texas) | 995.78 mi (1,602.56 km) |
| Wyandotte to Spanaway (Washington) | 1,938.26 mi (3,119.34 km) |
| Wyandotte to Spanish Fork (Utah) | 1,481.88 mi (2,384.85 km) |
| Wyandotte to Spanish Lake (Missouri) | 439.32 mi (707.01 km) |
| Wyandotte to Spanish Springs (Nevada) | 1,899.48 mi (3,056.92 km) |
| Wyandotte to Sparks (Nevada) | 1,903.57 mi (3,063.50 km) |
| Wyandotte to Spartanburg (South Carolina) | 506.47 mi (815.09 km) |
| Wyandotte to Spearfish (South Dakota) | 1,046.98 mi (1,684.95 km) |
| Wyandotte to Speedway (Indiana) | 232.13 mi (373.58 km) |
| Wyandotte to Spencer (Iowa) | 612.30 mi (985.40 km) |
| Wyandotte to Spokane (Washington) | 1,703.46 mi (2,741.45 km) |
