| Winter Garden to Scottsbluff (Nebraska) | 1,541.29 mi (2,480.47 km) |
| Winter Garden to Scottsboro (Alabama) | 496.24 mi (798.62 km) |
| Winter Garden to Scottsdale (Arizona) | 1,818.62 mi (2,926.78 km) |
| Winter Garden to Scranton (Pennsylvania) | 949.40 mi (1,527.92 km) |
| Winter Garden to Seabrook (Maryland) | 770.70 mi (1,240.32 km) |
| Winter Garden to Seabrook (Texas) | 813.60 mi (1,309.37 km) |
| Winter Garden to Seaford (New York) | 955.14 mi (1,537.16 km) |
| Winter Garden to Seagoville (Texas) | 932.33 mi (1,500.44 km) |
| Winter Garden to Seal Beach (California) | 2,175.25 mi (3,500.72 km) |
| Winter Garden to Searcy (Arkansas) | 752.92 mi (1,211.70 km) |
| Winter Garden to Seaside (California) | 2,389.11 mi (3,844.91 km) |
| Winter Garden to SeaTac (Washington) | 2,531.82 mi (4,074.57 km) |
| Winter Garden to Seattle (Washington) | 2,536.42 mi (4,081.98 km) |
| Winter Garden to Sebastian (Florida) | 85.84 mi (138.14 km) |
| Winter Garden to Sebring (Florida) | 74.11 mi (119.27 km) |
