| Wilmington to Sunset (Florida) | 605.76 mi (974.88 km) |
| Wilmington to Superior (Colorado) | 1,547.91 mi (2,491.12 km) |
| Wilmington to Superior (Wisconsin) | 1,137.04 mi (1,829.89 km) |
| Wilmington to Surprise (Arizona) | 1,971.90 mi (3,173.47 km) |
| Wilmington to Susanville (California) | 2,363.29 mi (3,803.35 km) |
| Wilmington to Sussex (Wisconsin) | 830.03 mi (1,335.80 km) |
| Wilmington to Suwanee (Georgia) | 353.68 mi (569.20 km) |
| Wilmington to Swansea (Illinois) | 736.05 mi (1,184.56 km) |
| Wilmington to Sweetwater (Florida) | 601.23 mi (967.59 km) |
| Wilmington to Sweetwater (Texas) | 1,302.95 mi (2,096.90 km) |
| Wilmington to Sycamore (Illinois) | 794.98 mi (1,279.40 km) |
| Wilmington to Sylacauga (Alabama) | 486.49 mi (782.93 km) |
| Wilmington to Sylvania (Ohio) | 607.21 mi (977.22 km) |
| Wilmington to Syosset (New York) | 515.63 mi (829.83 km) |
| Wilmington to Syracuse (New York) | 617.32 mi (993.48 km) |
