| Wilmington to Southchase (Florida) | 452.77 mi (728.67 km) |
| Wilmington to Southern Pines (North Carolina) | 109.72 mi (176.58 km) |
| Wilmington to Southfield (Michigan) | 640.77 mi (1,031.22 km) |
| Wilmington to Southgate (Michigan) | 622.99 mi (1,002.61 km) |
| Wilmington to Southlake (Texas) | 1,110.57 mi (1,787.29 km) |
| Wilmington to Spanaway (Washington) | 2,459.56 mi (3,958.28 km) |
| Wilmington to Spanish Fork (Utah) | 1,890.83 mi (3,042.99 km) |
| Wilmington to Spanish Lake (Missouri) | 753.05 mi (1,211.92 km) |
| Wilmington to Spanish Springs (Nevada) | 2,316.95 mi (3,728.77 km) |
| Wilmington to Sparks (Nevada) | 2,319.84 mi (3,733.43 km) |
| Wilmington to Spartanburg (South Carolina) | 235.26 mi (378.62 km) |
| Wilmington to Spearfish (South Dakota) | 1,547.55 mi (2,490.54 km) |
| Wilmington to Speedway (Indiana) | 600.93 mi (967.11 km) |
| Wilmington to Spencer (Iowa) | 1,113.99 mi (1,792.79 km) |
| Wilmington to Spokane (Washington) | 2,233.14 mi (3,593.88 km) |
