| Wilmington to Scottsbluff (Nebraska) | 1,492.06 mi (2,401.24 km) |
| Wilmington to Scottsboro (Alabama) | 466.03 mi (750.00 km) |
| Wilmington to Scottsdale (Arizona) | 1,938.71 mi (3,120.06 km) |
| Wilmington to Scranton (Pennsylvania) | 511.62 mi (823.37 km) |
| Wilmington to Seabrook (Maryland) | 334.56 mi (538.43 km) |
| Wilmington to Seabrook (Texas) | 1,053.51 mi (1,695.45 km) |
| Wilmington to Seaford (New York) | 506.98 mi (815.91 km) |
| Wilmington to Seagoville (Texas) | 1,079.75 mi (1,737.69 km) |
| Wilmington to Seal Beach (California) | 2,287.29 mi (3,681.03 km) |
| Wilmington to Searcy (Arkansas) | 788.99 mi (1,269.76 km) |
| Wilmington to Seaside (California) | 2,457.90 mi (3,955.60 km) |
| Wilmington to SeaTac (Washington) | 2,455.88 mi (3,952.35 km) |
| Wilmington to Seattle (Washington) | 2,458.25 mi (3,956.17 km) |
| Wilmington to Sebastian (Florida) | 469.90 mi (756.24 km) |
| Wilmington to Sebring (Florida) | 510.94 mi (822.28 km) |
