| West Des Moines to Sunset (Florida) | 1,336.31 mi (2,150.58 km) |
| West Des Moines to Superior (Colorado) | 605.56 mi (974.55 km) |
| West Des Moines to Superior (Wisconsin) | 365.10 mi (587.57 km) |
| West Des Moines to Surprise (Arizona) | 1,154.06 mi (1,857.29 km) |
| West Des Moines to Susanville (California) | 1,396.04 mi (2,246.71 km) |
| West Des Moines to Sussex (Wisconsin) | 304.09 mi (489.39 km) |
| West Des Moines to Suwanee (Georgia) | 740.52 mi (1,191.75 km) |
| West Des Moines to Swansea (Illinois) | 288.53 mi (464.35 km) |
| West Des Moines to Sweetwater (Florida) | 1,331.29 mi (2,142.51 km) |
| West Des Moines to Sweetwater (Texas) | 725.79 mi (1,168.05 km) |
| West Des Moines to Sycamore (Illinois) | 264.46 mi (425.61 km) |
| West Des Moines to Sylacauga (Alabama) | 710.20 mi (1,142.95 km) |
| West Des Moines to Sylvania (Ohio) | 519.93 mi (836.75 km) |
| West Des Moines to Syosset (New York) | 1,053.28 mi (1,695.10 km) |
| West Des Moines to Syracuse (New York) | 905.51 mi (1,457.28 km) |
