| West Des Moines to Stony Brook (New York) | 1,071.57 mi (1,724.52 km) |
| West Des Moines to Storm Lake (Iowa) | 104.63 mi (168.38 km) |
| West Des Moines to Storrs (Connecticut) | 1,108.21 mi (1,783.49 km) |
| West Des Moines to Stoughton (Wisconsin) | 251.64 mi (404.98 km) |
| West Des Moines to Stow (Ohio) | 640.21 mi (1,030.31 km) |
| West Des Moines to Streamwood (Illinois) | 290.40 mi (467.35 km) |
| West Des Moines to Streator (Illinois) | 258.49 mi (416.01 km) |
| West Des Moines to Streetsboro (Ohio) | 644.32 mi (1,036.94 km) |
| West Des Moines to Strongsville (Ohio) | 618.72 mi (995.74 km) |
| West Des Moines to Stuart (Florida) | 1,253.54 mi (2,017.39 km) |
| West Des Moines to Stuarts Draft (Virginia) | 818.86 mi (1,317.82 km) |
| West Des Moines to Sturgis (Michigan) | 431.72 mi (694.78 km) |
| West Des Moines to Suamico (Wisconsin) | 358.25 mi (576.55 km) |
| West Des Moines to Sudley (Virginia) | 879.29 mi (1,415.08 km) |
| West Des Moines to Suffern (New York) | 1,017.12 mi (1,636.89 km) |
