| West Des Moines to St. Petersburg (Florida) | 1,139.12 mi (1,833.23 km) |
| West Des Moines to St. Simons (Georgia) | 992.64 mi (1,597.50 km) |
| West Des Moines to Stafford (Texas) | 829.96 mi (1,335.70 km) |
| West Des Moines to Stallings (North Carolina) | 837.58 mi (1,347.95 km) |
| West Des Moines to Stamford (Connecticut) | 1,047.28 mi (1,685.44 km) |
| West Des Moines to Stanford (California) | 1,533.07 mi (2,467.24 km) |
| West Des Moines to Stanton (California) | 1,422.25 mi (2,288.89 km) |
| West Des Moines to Star (Idaho) | 1,160.37 mi (1,867.43 km) |
| West Des Moines to Starkville (Mississippi) | 621.15 mi (999.64 km) |
| West Des Moines to State College (Pennsylvania) | 828.68 mi (1,333.64 km) |
| West Des Moines to Staten Island (New York) | 1,022.59 mi (1,645.71 km) |
| West Des Moines to Statesboro (Georgia) | 912.38 mi (1,468.33 km) |
| West Des Moines to Statesville (North Carolina) | 801.13 mi (1,289.29 km) |
| West Des Moines to Staunton (Virginia) | 813.97 mi (1,309.96 km) |
| West Des Moines to Steamboat Springs (Colorado) | 683.39 mi (1,099.81 km) |
