| West Des Moines to Southchase (Florida) | 1,146.54 mi (1,845.18 km) |
| West Des Moines to Southern Pines (North Carolina) | 892.48 mi (1,436.30 km) |
| West Des Moines to Southfield (Michigan) | 543.45 mi (874.60 km) |
| West Des Moines to Southgate (Michigan) | 545.53 mi (877.95 km) |
| West Des Moines to Southlake (Texas) | 622.13 mi (1,001.22 km) |
| West Des Moines to Spanaway (Washington) | 1,457.61 mi (2,345.80 km) |
| West Des Moines to Spanish Fork (Utah) | 937.30 mi (1,508.44 km) |
| West Des Moines to Spanish Lake (Missouri) | 268.37 mi (431.89 km) |
| West Des Moines to Spanish Springs (Nevada) | 1,359.23 mi (2,187.47 km) |
| West Des Moines to Sparks (Nevada) | 1,363.03 mi (2,193.59 km) |
| West Des Moines to Spartanburg (South Carolina) | 787.65 mi (1,267.61 km) |
| West Des Moines to Spearfish (South Dakota) | 545.59 mi (878.05 km) |
| West Des Moines to Speedway (Indiana) | 412.84 mi (664.40 km) |
| West Des Moines to Spencer (Iowa) | 130.59 mi (210.16 km) |
| West Des Moines to Spokane (Washington) | 1,231.86 mi (1,982.49 km) |
