| West Des Moines to Smithville (Missouri) | 154.98 mi (249.42 km) |
| West Des Moines to Smyrna (Delaware) | 966.64 mi (1,555.66 km) |
| West Des Moines to Smyrna (Georgia) | 733.05 mi (1,179.73 km) |
| West Des Moines to Smyrna (Tennessee) | 548.76 mi (883.15 km) |
| West Des Moines to Snellville (Georgia) | 752.94 mi (1,211.74 km) |
| West Des Moines to Snoqualmie (Washington) | 1,433.34 mi (2,306.74 km) |
| West Des Moines to Snyder (Texas) | 725.50 mi (1,167.57 km) |
| West Des Moines to Socastee (South Carolina) | 971.93 mi (1,564.18 km) |
| West Des Moines to Socorro (Texas) | 971.89 mi (1,564.11 km) |
| West Des Moines to Soddy-Daisy (Tennessee) | 636.83 mi (1,024.87 km) |
| West Des Moines to Solana Beach (California) | 1,413.73 mi (2,275.18 km) |
| West Des Moines to Soledad (California) | 1,514.53 mi (2,437.40 km) |
| West Des Moines to Solon (Ohio) | 638.46 mi (1,027.50 km) |
| West Des Moines to Somers Point (New Jersey) | 1,017.96 mi (1,638.24 km) |
| West Des Moines to Somerset (Kentucky) | 578.80 mi (931.49 km) |
