| West Des Moines to Siloam Springs (Arkansas) | 373.06 mi (600.38 km) |
| West Des Moines to Silver Firs (Washington) | 1,450.27 mi (2,333.98 km) |
| West Des Moines to Silver Spring (Maryland) | 899.33 mi (1,447.33 km) |
| West Des Moines to Silver Springs Shores (Florida) | 1,083.37 mi (1,743.51 km) |
| West Des Moines to Silverdale (Washington) | 1,473.34 mi (2,371.12 km) |
| West Des Moines to Silverton (Oregon) | 1,470.04 mi (2,365.80 km) |
| West Des Moines to Simi Valley (California) | 1,444.93 mi (2,325.39 km) |
| West Des Moines to Simpsonville (South Carolina) | 782.68 mi (1,259.60 km) |
| West Des Moines to Sioux City (Iowa) | 148.96 mi (239.73 km) |
| West Des Moines to Sioux Falls (South Dakota) | 203.48 mi (327.47 km) |
| West Des Moines to Skokie (Illinois) | 312.89 mi (503.55 km) |
| West Des Moines to Sleepy Hollow (New York) | 1,031.23 mi (1,659.60 km) |
| West Des Moines to Slidell (Louisiana) | 809.48 mi (1,302.73 km) |
| West Des Moines to Smithfield (North Carolina) | 930.69 mi (1,497.80 km) |
| West Des Moines to Smithfield (Utah) | 929.53 mi (1,495.94 km) |
