| West Des Moines to Shelbyville (Tennessee) | 575.64 mi (926.41 km) |
| West Des Moines to Shelton (Connecticut) | 1,066.95 mi (1,717.09 km) |
| West Des Moines to Shelton (Washington) | 1,490.53 mi (2,398.78 km) |
| West Des Moines to Shenandoah (Louisiana) | 785.79 mi (1,264.60 km) |
| West Des Moines to Shepherdsville (Kentucky) | 494.67 mi (796.10 km) |
| West Des Moines to Sheridan (Wyoming) | 700.13 mi (1,126.76 km) |
| West Des Moines to Sherman (Texas) | 569.13 mi (915.92 km) |
| West Des Moines to Sherrelwood (Colorado) | 599.14 mi (964.23 km) |
| West Des Moines to Sherwood (Arkansas) | 470.85 mi (757.77 km) |
| West Des Moines to Sherwood (Oregon) | 1,472.82 mi (2,370.28 km) |
| West Des Moines to Shiloh (Illinois) | 290.97 mi (468.27 km) |
| West Des Moines to Shiloh (Ohio) | 514.19 mi (827.51 km) |
| West Des Moines to Shiloh (Pennsylvania) | 894.25 mi (1,439.16 km) |
| West Des Moines to Shirley (New York) | 1,085.88 mi (1,747.56 km) |
| West Des Moines to Shively (Kentucky) | 481.59 mi (775.05 km) |
