| West Des Moines to Seymour (Indiana) | 453.07 mi (729.14 km) |
| West Des Moines to Seymour (Tennessee) | 666.43 mi (1,072.52 km) |
| West Des Moines to Shady Hills (Florida) | 1,106.75 mi (1,781.14 km) |
| West Des Moines to Shafter (California) | 1,430.88 mi (2,302.77 km) |
| West Des Moines to Shaker Heights (Ohio) | 632.29 mi (1,017.58 km) |
| West Des Moines to Shakopee (Minnesota) | 223.17 mi (359.16 km) |
| West Des Moines to Sharon (Pennsylvania) | 688.06 mi (1,107.32 km) |
| West Des Moines to Sharonville (Ohio) | 517.10 mi (832.19 km) |
| West Des Moines to Shasta Lake (California) | 1,482.99 mi (2,386.64 km) |
| West Des Moines to Shawnee (Kansas) | 183.41 mi (295.17 km) |
| West Des Moines to Shawnee (Oklahoma) | 461.57 mi (742.82 km) |
| West Des Moines to Sheboygan (Wisconsin) | 342.47 mi (551.15 km) |
| West Des Moines to Shelby (North Carolina) | 789.91 mi (1,271.24 km) |
| West Des Moines to Shelbyville (Indiana) | 442.41 mi (712.00 km) |
| West Des Moines to Shelbyville (Kentucky) | 508.60 mi (818.51 km) |
