| West Des Moines to Scottsbluff (Nebraska) | 509.84 mi (820.51 km) |
| West Des Moines to Scottsboro (Alabama) | 635.49 mi (1,022.72 km) |
| West Des Moines to Scottsdale (Arizona) | 1,125.84 mi (1,811.86 km) |
| West Des Moines to Scranton (Pennsylvania) | 936.10 mi (1,506.50 km) |
| West Des Moines to Seabrook (Maryland) | 908.55 mi (1,462.16 km) |
| West Des Moines to Seabrook (Texas) | 830.45 mi (1,336.47 km) |
| West Des Moines to Seaford (New York) | 1,055.51 mi (1,698.69 km) |
| West Des Moines to Seagoville (Texas) | 633.36 mi (1,019.30 km) |
| West Des Moines to Seal Beach (California) | 1,427.71 mi (2,297.68 km) |
| West Des Moines to Searcy (Arkansas) | 449.81 mi (723.90 km) |
| West Des Moines to Seaside (California) | 1,534.57 mi (2,469.65 km) |
| West Des Moines to SeaTac (Washington) | 1,453.96 mi (2,339.93 km) |
| West Des Moines to Seattle (Washington) | 1,456.42 mi (2,343.89 km) |
| West Des Moines to Sebastian (Florida) | 1,211.92 mi (1,950.40 km) |
| West Des Moines to Sebring (Florida) | 1,196.53 mi (1,925.63 km) |
