| West Des Moines to Santa Paula (California) | 1,458.13 mi (2,346.63 km) |
| West Des Moines to Santa Rosa (California) | 1,538.69 mi (2,476.27 km) |
| West Des Moines to Santaquin (Utah) | 947.27 mi (1,524.49 km) |
| West Des Moines to Santee (California) | 1,405.34 mi (2,261.68 km) |
| West Des Moines to Sapulpa (Oklahoma) | 402.80 mi (648.25 km) |
| West Des Moines to Saraland (Alabama) | 804.05 mi (1,294.00 km) |
| West Des Moines to Sarasota (Florida) | 1,170.00 mi (1,882.93 km) |
| West Des Moines to Sarasota Springs (Florida) | 1,173.90 mi (1,889.21 km) |
| West Des Moines to Saratoga (California) | 1,529.44 mi (2,461.40 km) |
| West Des Moines to Saratoga Springs (New York) | 1,024.96 mi (1,649.52 km) |
| West Des Moines to Saratoga Springs (Utah) | 948.30 mi (1,526.13 km) |
| West Des Moines to Sartell (Minnesota) | 281.84 mi (453.58 km) |
| West Des Moines to Satellite Beach (Florida) | 1,185.32 mi (1,907.59 km) |
| West Des Moines to Sauk Rapids (Minnesota) | 280.17 mi (450.90 km) |
| West Des Moines to Sault Ste. Marie (Michigan) | 577.75 mi (929.79 km) |
