| West Des Moines to Sanford (Florida) | 1,127.23 mi (1,814.10 km) |
| West Des Moines to Sanford (Maine) | 1,176.37 mi (1,893.18 km) |
| West Des Moines to Sanford (North Carolina) | 892.08 mi (1,435.66 km) |
| West Des Moines to Sanger (California) | 1,415.99 mi (2,278.82 km) |
| West Des Moines to Santa Ana (California) | 1,418.81 mi (2,283.36 km) |
| West Des Moines to Santa Barbara (California) | 1,488.99 mi (2,396.29 km) |
| West Des Moines to Santa Clara (California) | 1,524.17 mi (2,452.92 km) |
| West Des Moines to Santa Clara (Oregon) | 1,489.81 mi (2,397.61 km) |
| West Des Moines to Santa Clarita (California) | 1,427.32 mi (2,297.05 km) |
| West Des Moines to Santa Cruz (California) | 1,536.81 mi (2,473.26 km) |
| West Des Moines to Santa Fe (New Mexico) | 773.22 mi (1,244.37 km) |
| West Des Moines to Santa Fe (Texas) | 843.64 mi (1,357.71 km) |
| West Des Moines to Santa Fe Springs (California) | 1,421.27 mi (2,287.31 km) |
| West Des Moines to Santa Maria (California) | 1,510.37 mi (2,430.71 km) |
| West Des Moines to Santa Monica (California) | 1,439.31 mi (2,316.35 km) |
