| West Des Moines to Sacramento (California) | 1,472.21 mi (2,369.30 km) |
| West Des Moines to Saddlebrooke (Arizona) | 1,125.71 mi (1,811.66 km) |
| West Des Moines to Safety Harbor (Florida) | 1,125.38 mi (1,811.12 km) |
| West Des Moines to Saginaw (Michigan) | 516.90 mi (831.87 km) |
| West Des Moines to Saginaw (Texas) | 631.59 mi (1,016.45 km) |
| West Des Moines to Sahuarita (Arizona) | 1,157.12 mi (1,862.21 km) |
| West Des Moines to Saks (Alabama) | 693.30 mi (1,115.76 km) |
| West Des Moines to Salem (Massachusetts) | 1,172.44 mi (1,886.85 km) |
| West Des Moines to Salem (Ohio) | 672.82 mi (1,082.81 km) |
| West Des Moines to Salem (Oregon) | 1,482.06 mi (2,385.14 km) |
| West Des Moines to Salem (Virginia) | 788.52 mi (1,269.00 km) |
| West Des Moines to Salem Lakes (Wisconsin) | 297.71 mi (479.13 km) |
| West Des Moines to Salida (California) | 1,470.62 mi (2,366.73 km) |
| West Des Moines to Salina (Kansas) | 276.99 mi (445.77 km) |
| West Des Moines to Salinas (California) | 1,523.20 mi (2,451.35 km) |
