| West Des Moines to Oskaloosa (Iowa) | 61.74 mi (99.36 km) |
| West Des Moines to Oswego (Illinois) | 281.27 mi (452.66 km) |
| West Des Moines to Oswego (New York) | 888.32 mi (1,429.61 km) |
| West Des Moines to Otsego (Minnesota) | 256.73 mi (413.17 km) |
| West Des Moines to Ottawa (Illinois) | 256.89 mi (413.43 km) |
| West Des Moines to Ottawa (Kansas) | 218.54 mi (351.70 km) |
| West Des Moines to Ottumwa (Iowa) | 79.71 mi (128.29 km) |
| West Des Moines to Overland (Missouri) | 267.19 mi (430.00 km) |
| West Des Moines to Overland Park (Kansas) | 190.25 mi (306.17 km) |
| West Des Moines to Overlea (Maryland) | 918.45 mi (1,478.10 km) |
| West Des Moines to Oviedo (Florida) | 1,137.72 mi (1,830.99 km) |
| West Des Moines to Owasso (Oklahoma) | 380.03 mi (611.60 km) |
| West Des Moines to Owatonna (Minnesota) | 177.63 mi (285.87 km) |
| West Des Moines to Owensboro (Kentucky) | 440.66 mi (709.18 km) |
| West Des Moines to Owings Mills (Maryland) | 903.48 mi (1,454.01 km) |
