| West Des Moines to Orangeburg (South Carolina) | 898.75 mi (1,446.41 km) |
| West Des Moines to Orangevale (California) | 1,457.02 mi (2,344.84 km) |
| West Des Moines to Orchards (Washington) | 1,457.89 mi (2,346.24 km) |
| West Des Moines to Orcutt (California) | 1,511.23 mi (2,432.08 km) |
| West Des Moines to Oregon (Ohio) | 534.39 mi (860.02 km) |
| West Des Moines to Oregon (Wisconsin) | 243.81 mi (392.37 km) |
| West Des Moines to Oregon City (Oregon) | 1,460.67 mi (2,350.72 km) |
| West Des Moines to Orem (Utah) | 937.75 mi (1,509.16 km) |
| West Des Moines to Orinda (California) | 1,523.39 mi (2,451.65 km) |
| West Des Moines to Orland Park (Illinois) | 305.87 mi (492.24 km) |
| West Des Moines to Orlando (Florida) | 1,142.78 mi (1,839.13 km) |
| West Des Moines to Ormond Beach (Florida) | 1,104.90 mi (1,778.16 km) |
| West Des Moines to Oro Valley (Arizona) | 1,136.28 mi (1,828.67 km) |
| West Des Moines to Oroville (California) | 1,459.66 mi (2,349.09 km) |
| West Des Moines to Oshkosh (Wisconsin) | 314.80 mi (506.63 km) |
