| West Des Moines to Olympia (Washington) | 1,479.48 mi (2,381.00 km) |
| West Des Moines to Olympia Heights (Florida) | 1,335.71 mi (2,149.62 km) |
| West Des Moines to Omaha (Nebraska) | 119.44 mi (192.21 km) |
| West Des Moines to On Top of the World Designated Place (Florida) | 1,074.56 mi (1,729.34 km) |
| West Des Moines to Onalaska (Wisconsin) | 207.62 mi (334.13 km) |
| West Des Moines to Oneida (New York) | 929.84 mi (1,496.43 km) |
| West Des Moines to Oneonta (New York) | 960.91 mi (1,546.44 km) |
| West Des Moines to Ontario (California) | 1,394.83 mi (2,244.77 km) |
| West Des Moines to Ontario (Oregon) | 1,184.45 mi (1,906.19 km) |
| West Des Moines to Opa-locka (Florida) | 1,328.16 mi (2,137.47 km) |
| West Des Moines to Opelika (Alabama) | 768.43 mi (1,236.67 km) |
| West Des Moines to Opelousas (Louisiana) | 767.73 mi (1,235.54 km) |
| West Des Moines to Orange (California) | 1,413.53 mi (2,274.86 km) |
| West Des Moines to Orange (Texas) | 789.70 mi (1,270.90 km) |
| West Des Moines to Orange City (Florida) | 1,118.59 mi (1,800.19 km) |
