| West Des Moines to Enterprise (Nevada) | 1,213.22 mi (1,952.49 km) |
| West Des Moines to Enumclaw (Washington) | 1,437.94 mi (2,314.15 km) |
| West Des Moines to Ephrata (Pennsylvania) | 922.83 mi (1,485.15 km) |
| West Des Moines to Erie (Colorado) | 597.67 mi (961.85 km) |
| West Des Moines to Erie (Pennsylvania) | 705.97 mi (1,136.14 km) |
| West Des Moines to Erlanger (Kentucky) | 515.13 mi (829.02 km) |
| West Des Moines to Escanaba (Michigan) | 442.35 mi (711.89 km) |
| West Des Moines to Escondido (California) | 1,399.52 mi (2,252.32 km) |
| West Des Moines to Española (New Mexico) | 763.77 mi (1,229.16 km) |
| West Des Moines to Essex (Maryland) | 923.31 mi (1,485.93 km) |
| West Des Moines to Essex Junction (Vermont) | 1,060.50 mi (1,706.71 km) |
| West Des Moines to Estelle (Louisiana) | 834.59 mi (1,343.14 km) |
| West Des Moines to Estero (Florida) | 1,247.57 mi (2,007.78 km) |
| West Des Moines to Euclid (Ohio) | 633.30 mi (1,019.19 km) |
| West Des Moines to Eufaula (Alabama) | 818.90 mi (1,317.89 km) |
