| West Des Moines to Elyria (Ohio) | 604.13 mi (972.26 km) |
| West Des Moines to Emeryville (California) | 1,530.23 mi (2,462.67 km) |
| West Des Moines to Emmaus (Pennsylvania) | 953.53 mi (1,534.56 km) |
| West Des Moines to Emporia (Kansas) | 252.29 mi (406.02 km) |
| West Des Moines to Encinitas (California) | 1,411.93 mi (2,272.28 km) |
| West Des Moines to Endicott (New York) | 911.33 mi (1,466.64 km) |
| West Des Moines to Endwell (New York) | 913.39 mi (1,469.96 km) |
| West Des Moines to Englewood (Colorado) | 602.35 mi (969.39 km) |
| West Des Moines to Englewood (Florida) | 1,197.82 mi (1,927.71 km) |
| West Des Moines to Englewood (New Jersey) | 1,028.11 mi (1,654.59 km) |
| West Des Moines to Englewood (Ohio) | 509.41 mi (819.82 km) |
| West Des Moines to Enid (Oklahoma) | 417.79 mi (672.37 km) |
| West Des Moines to Ennis (Texas) | 656.59 mi (1,056.67 km) |
| West Des Moines to Ensley (Florida) | 843.48 mi (1,357.46 km) |
| West Des Moines to Enterprise (Alabama) | 831.93 mi (1,338.86 km) |
