| Weslaco to Sunset (Florida) | 1,095.36 mi (1,762.81 km) |
| Weslaco to Superior (Colorado) | 1,037.43 mi (1,669.58 km) |
| Weslaco to Superior (Wisconsin) | 1,455.20 mi (2,341.92 km) |
| Weslaco to Surprise (Arizona) | 1,008.54 mi (1,623.09 km) |
| Weslaco to Susanville (California) | 1,628.30 mi (2,620.49 km) |
| Weslaco to Sussex (Wisconsin) | 1,295.33 mi (2,084.64 km) |
| Weslaco to Suwanee (Georgia) | 993.17 mi (1,598.36 km) |
| Weslaco to Swansea (Illinois) | 974.21 mi (1,567.84 km) |
| Weslaco to Sweetwater (Florida) | 1,093.47 mi (1,759.76 km) |
| Weslaco to Sweetwater (Texas) | 459.65 mi (739.73 km) |
| Weslaco to Sycamore (Illinois) | 1,215.02 mi (1,955.38 km) |
| Weslaco to Sylacauga (Alabama) | 853.91 mi (1,374.23 km) |
| Weslaco to Sylvania (Ohio) | 1,346.66 mi (2,167.23 km) |
| Weslaco to Syosset (New York) | 1,726.74 mi (2,778.92 km) |
| Weslaco to Syracuse (New York) | 1,694.23 mi (2,726.60 km) |
