| Weslaco to St. Petersburg (Florida) | 949.58 mi (1,528.20 km) |
| Weslaco to St. Simons (Georgia) | 1,063.15 mi (1,710.97 km) |
| Weslaco to Stafford (Texas) | 281.53 mi (453.07 km) |
| Weslaco to Stallings (North Carolina) | 1,198.73 mi (1,929.18 km) |
| Weslaco to Stamford (Connecticut) | 1,733.69 mi (2,790.10 km) |
| Weslaco to Stanford (California) | 1,612.38 mi (2,594.87 km) |
| Weslaco to Stanton (California) | 1,305.50 mi (2,101.00 km) |
| Weslaco to Star (Idaho) | 1,594.78 mi (2,566.56 km) |
| Weslaco to Starkville (Mississippi) | 744.93 mi (1,198.85 km) |
| Weslaco to State College (Pennsylvania) | 1,531.91 mi (2,465.37 km) |
| Weslaco to Staten Island (New York) | 1,689.27 mi (2,718.62 km) |
| Weslaco to Statesboro (Georgia) | 1,067.26 mi (1,717.59 km) |
| Weslaco to Statesville (North Carolina) | 1,209.68 mi (1,946.79 km) |
| Weslaco to Staunton (Virginia) | 1,378.38 mi (2,218.29 km) |
| Weslaco to Steamboat Springs (Colorado) | 1,111.60 mi (1,788.95 km) |
