| Weslaco to Southchase (Florida) | 1,029.93 mi (1,657.51 km) |
| Weslaco to Southern Pines (North Carolina) | 1,265.33 mi (2,036.35 km) |
| Weslaco to Southfield (Michigan) | 1,401.61 mi (2,255.67 km) |
| Weslaco to Southgate (Michigan) | 1,389.39 mi (2,236.01 km) |
| Weslaco to Southlake (Texas) | 472.15 mi (759.84 km) |
| Weslaco to Spanaway (Washington) | 1,965.67 mi (3,163.45 km) |
| Weslaco to Spanish Fork (Utah) | 1,243.01 mi (2,000.43 km) |
| Weslaco to Spanish Lake (Missouri) | 982.37 mi (1,580.97 km) |
| Weslaco to Spanish Springs (Nevada) | 1,558.59 mi (2,508.31 km) |
| Weslaco to Sparks (Nevada) | 1,557.86 mi (2,507.14 km) |
| Weslaco to Spartanburg (South Carolina) | 1,129.86 mi (1,818.34 km) |
| Weslaco to Spearfish (South Dakota) | 1,307.56 mi (2,104.32 km) |
| Weslaco to Speedway (Indiana) | 1,159.71 mi (1,866.38 km) |
| Weslaco to Spencer (Iowa) | 1,184.49 mi (1,906.25 km) |
| Weslaco to Spokane (Washington) | 1,822.45 mi (2,932.94 km) |
