| Weslaco to Smithville (Missouri) | 935.28 mi (1,505.19 km) |
| Weslaco to Smyrna (Delaware) | 1,578.78 mi (2,540.80 km) |
| Weslaco to Smyrna (Georgia) | 964.44 mi (1,552.12 km) |
| Weslaco to Smyrna (Tennessee) | 957.43 mi (1,540.84 km) |
| Weslaco to Snellville (Georgia) | 989.86 mi (1,593.03 km) |
| Weslaco to Snoqualmie (Washington) | 1,963.62 mi (3,160.15 km) |
| Weslaco to Snyder (Texas) | 485.71 mi (781.67 km) |
| Weslaco to Socastee (South Carolina) | 1,247.19 mi (2,007.16 km) |
| Weslaco to Socorro (Texas) | 627.06 mi (1,009.15 km) |
| Weslaco to Soddy-Daisy (Tennessee) | 985.58 mi (1,586.14 km) |
| Weslaco to Solana Beach (California) | 1,248.00 mi (2,008.47 km) |
| Weslaco to Soledad (California) | 1,545.28 mi (2,486.89 km) |
| Weslaco to Solon (Ohio) | 1,412.66 mi (2,273.46 km) |
| Weslaco to Somers Point (New Jersey) | 1,626.97 mi (2,618.35 km) |
| Weslaco to Somerset (Kentucky) | 1,088.23 mi (1,751.34 km) |
