| Weslaco to Siloam Springs (Arkansas) | 721.98 mi (1,161.91 km) |
| Weslaco to Silver Firs (Washington) | 1,989.50 mi (3,201.79 km) |
| Weslaco to Silver Spring (Maryland) | 1,502.90 mi (2,418.68 km) |
| Weslaco to Silver Springs Shores (Florida) | 997.90 mi (1,605.96 km) |
| Weslaco to Silverdale (Washington) | 1,999.82 mi (3,218.41 km) |
| Weslaco to Silverton (Oregon) | 1,892.34 mi (3,045.43 km) |
| Weslaco to Simi Valley (California) | 1,356.78 mi (2,183.53 km) |
| Weslaco to Simpsonville (South Carolina) | 1,106.25 mi (1,780.34 km) |
| Weslaco to Sioux City (Iowa) | 1,132.32 mi (1,822.30 km) |
| Weslaco to Sioux Falls (South Dakota) | 1,202.89 mi (1,935.87 km) |
| Weslaco to Skokie (Illinois) | 1,241.57 mi (1,998.11 km) |
| Weslaco to Sleepy Hollow (New York) | 1,719.07 mi (2,766.58 km) |
| Weslaco to Slidell (Louisiana) | 574.96 mi (925.32 km) |
| Weslaco to Smithfield (North Carolina) | 1,328.61 mi (2,138.20 km) |
| Weslaco to Smithfield (Utah) | 1,338.32 mi (2,153.82 km) |
