| Weslaco to Scottsbluff (Nebraska) | 1,132.25 mi (1,822.18 km) |
| Weslaco to Scottsboro (Alabama) | 920.56 mi (1,481.49 km) |
| Weslaco to Scottsdale (Arizona) | 978.90 mi (1,575.39 km) |
| Weslaco to Scranton (Pennsylvania) | 1,650.29 mi (2,655.89 km) |
| Weslaco to Seabrook (Maryland) | 1,510.07 mi (2,430.22 km) |
| Weslaco to Seabrook (Texas) | 297.39 mi (478.61 km) |
| Weslaco to Seaford (New York) | 1,722.37 mi (2,771.89 km) |
| Weslaco to Seagoville (Texas) | 456.93 mi (735.36 km) |
| Weslaco to Seal Beach (California) | 1,308.74 mi (2,106.21 km) |
| Weslaco to Searcy (Arkansas) | 728.77 mi (1,172.85 km) |
| Weslaco to Seaside (California) | 1,574.44 mi (2,533.82 km) |
| Weslaco to SeaTac (Washington) | 1,976.25 mi (3,180.47 km) |
| Weslaco to Seattle (Washington) | 1,984.96 mi (3,194.48 km) |
| Weslaco to Sebastian (Florida) | 1,082.86 mi (1,742.70 km) |
| Weslaco to Sebring (Florida) | 1,022.85 mi (1,646.12 km) |
