| Weslaco to Santa Paula (California) | 1,375.85 mi (2,214.22 km) |
| Weslaco to Santa Rosa (California) | 1,666.60 mi (2,682.13 km) |
| Weslaco to Santaquin (Utah) | 1,241.65 mi (1,998.25 km) |
| Weslaco to Santee (California) | 1,230.08 mi (1,979.63 km) |
| Weslaco to Sapulpa (Oklahoma) | 689.57 mi (1,109.76 km) |
| Weslaco to Saraland (Alabama) | 681.72 mi (1,097.12 km) |
| Weslaco to Sarasota (Florida) | 955.77 mi (1,538.17 km) |
| Weslaco to Sarasota Springs (Florida) | 959.94 mi (1,544.87 km) |
| Weslaco to Saratoga (California) | 1,601.16 mi (2,576.82 km) |
| Weslaco to Saratoga Springs (New York) | 1,793.63 mi (2,886.57 km) |
| Weslaco to Saratoga Springs (Utah) | 1,264.77 mi (2,035.44 km) |
| Weslaco to Sartell (Minnesota) | 1,360.51 mi (2,189.52 km) |
| Weslaco to Satellite Beach (Florida) | 1,076.81 mi (1,732.96 km) |
| Weslaco to Sauk Rapids (Minnesota) | 1,359.67 mi (2,188.18 km) |
| Weslaco to Sault Ste. Marie (Michigan) | 1,590.33 mi (2,559.38 km) |
