| Weslaco to Sanford (Florida) | 1,039.51 mi (1,672.93 km) |
| Weslaco to Sanford (Maine) | 1,936.71 mi (3,116.83 km) |
| Weslaco to Sanford (North Carolina) | 1,285.45 mi (2,068.73 km) |
| Weslaco to Sanger (California) | 1,460.29 mi (2,350.11 km) |
| Weslaco to Santa Ana (California) | 1,298.03 mi (2,088.97 km) |
| Weslaco to Santa Barbara (California) | 1,412.89 mi (2,273.83 km) |
| Weslaco to Santa Clara (California) | 1,600.66 mi (2,576.02 km) |
| Weslaco to Santa Clara (Oregon) | 1,872.35 mi (3,013.26 km) |
| Weslaco to Santa Clarita (California) | 1,346.60 mi (2,167.14 km) |
| Weslaco to Santa Cruz (California) | 1,594.30 mi (2,565.77 km) |
| Weslaco to Santa Fe (New Mexico) | 808.97 mi (1,301.91 km) |
| Weslaco to Santa Fe (Texas) | 284.46 mi (457.79 km) |
| Weslaco to Santa Fe Springs (California) | 1,312.18 mi (2,111.75 km) |
| Weslaco to Santa Maria (California) | 1,462.79 mi (2,354.13 km) |
| Weslaco to Santa Monica (California) | 1,336.90 mi (2,151.53 km) |
