| Weslaco to San Clemente (California) | 1,276.97 mi (2,055.08 km) |
| Weslaco to San Diego (California) | 1,237.21 mi (1,991.09 km) |
| Weslaco to San Diego Country Estates (California) | 1,222.35 mi (1,967.18 km) |
| Weslaco to San Dimas (California) | 1,302.45 mi (2,096.09 km) |
| Weslaco to San Fernando (California) | 1,340.40 mi (2,157.17 km) |
| Weslaco to San Francisco (California) | 1,635.03 mi (2,631.33 km) |
| Weslaco to San Gabriel (California) | 1,317.80 mi (2,120.79 km) |
| Weslaco to San Germán (Puerto Rico) | 2,051.87 mi (3,302.17 km) |
| Weslaco to San Jacinto (California) | 1,251.10 mi (2,013.44 km) |
| Weslaco to San Jose (California) | 1,592.91 mi (2,563.54 km) |
| Weslaco to San Juan (Puerto Rico) | 2,104.45 mi (3,386.78 km) |
| Weslaco to San Juan (Texas) | 10.40 mi (16.74 km) |
| Weslaco to San Juan Capistrano (California) | 1,280.48 mi (2,060.73 km) |
| Weslaco to San Leandro (California) | 1,619.36 mi (2,606.10 km) |
| Weslaco to San Lorenzo (California) | 1,617.11 mi (2,602.48 km) |
