| Weslaco to Oskaloosa (Iowa) | 1,089.16 mi (1,752.83 km) |
| Weslaco to Oswego (Illinois) | 1,204.94 mi (1,939.17 km) |
| Weslaco to Oswego (New York) | 1,697.02 mi (2,731.08 km) |
| Weslaco to Otsego (Minnesota) | 1,342.11 mi (2,159.93 km) |
| Weslaco to Ottawa (Illinois) | 1,172.73 mi (1,887.32 km) |
| Weslaco to Ottawa (Kansas) | 873.95 mi (1,406.48 km) |
| Weslaco to Ottumwa (Iowa) | 1,074.94 mi (1,729.94 km) |
| Weslaco to Overland (Missouri) | 972.57 mi (1,565.20 km) |
| Weslaco to Overland Park (Kansas) | 899.95 mi (1,448.32 km) |
| Weslaco to Overlea (Maryland) | 1,538.71 mi (2,476.31 km) |
| Weslaco to Oviedo (Florida) | 1,043.93 mi (1,680.04 km) |
| Weslaco to Owasso (Oklahoma) | 711.21 mi (1,144.59 km) |
| Weslaco to Owatonna (Minnesota) | 1,267.17 mi (2,039.31 km) |
| Weslaco to Owensboro (Kentucky) | 1,022.17 mi (1,645.02 km) |
| Weslaco to Owings Mills (Maryland) | 1,527.71 mi (2,458.61 km) |
