| Weslaco to Orangeburg (South Carolina) | 1,142.38 mi (1,838.48 km) |
| Weslaco to Orangevale (California) | 1,600.55 mi (2,575.84 km) |
| Weslaco to Orchards (Washington) | 1,910.23 mi (3,074.21 km) |
| Weslaco to Orcutt (California) | 1,460.27 mi (2,350.08 km) |
| Weslaco to Oregon (Ohio) | 1,353.25 mi (2,177.85 km) |
| Weslaco to Oregon (Wisconsin) | 1,255.79 mi (2,021.00 km) |
| Weslaco to Oregon City (Oregon) | 1,898.46 mi (3,055.28 km) |
| Weslaco to Orem (Utah) | 1,254.61 mi (2,019.10 km) |
| Weslaco to Orinda (California) | 1,624.93 mi (2,615.08 km) |
| Weslaco to Orland Park (Illinois) | 1,213.02 mi (1,952.17 km) |
| Weslaco to Orlando (Florida) | 1,033.73 mi (1,663.62 km) |
| Weslaco to Ormond Beach (Florida) | 1,054.23 mi (1,696.62 km) |
| Weslaco to Oro Valley (Arizona) | 893.28 mi (1,437.60 km) |
| Weslaco to Oroville (California) | 1,641.97 mi (2,642.49 km) |
| Weslaco to Oshkosh (Wisconsin) | 1,342.11 mi (2,159.92 km) |
