| Weslaco to Enterprise (Nevada) | 1,223.23 mi (1,968.60 km) |
| Weslaco to Enumclaw (Washington) | 1,954.42 mi (3,145.34 km) |
| Weslaco to Ephrata (Pennsylvania) | 1,582.73 mi (2,547.17 km) |
| Weslaco to Erie (Colorado) | 1,041.38 mi (1,675.94 km) |
| Weslaco to Erie (Pennsylvania) | 1,498.72 mi (2,411.95 km) |
| Weslaco to Erlanger (Kentucky) | 1,179.23 mi (1,897.79 km) |
| Weslaco to Escanaba (Michigan) | 1,481.01 mi (2,383.45 km) |
| Weslaco to Escondido (California) | 1,240.70 mi (1,996.72 km) |
| Weslaco to Española (New Mexico) | 830.68 mi (1,336.85 km) |
| Weslaco to Essex (Maryland) | 1,539.95 mi (2,478.30 km) |
| Weslaco to Essex Junction (Vermont) | 1,875.46 mi (3,018.26 km) |
| Weslaco to Estelle (Louisiana) | 544.06 mi (875.59 km) |
| Weslaco to Estero (Florida) | 1,002.55 mi (1,613.45 km) |
| Weslaco to Euclid (Ohio) | 1,419.33 mi (2,284.20 km) |
| Weslaco to Eufaula (Alabama) | 870.45 mi (1,400.85 km) |
