| Villanueva de la Serena to Southern Pines (North Carolina) | 3,951.74 mi (6,359.71 km) |
| Villanueva de la Serena to Southfield (Michigan) | 3,916.88 mi (6,303.61 km) |
| Villanueva de la Serena to Southgate (Michigan) | 3,922.22 mi (6,312.21 km) |
| Villanueva de la Serena to Southlake (Texas) | 4,900.83 mi (7,887.12 km) |
| Villanueva de la Serena to Spanaway (Washington) | 5,326.20 mi (8,571.68 km) |
| Villanueva de la Serena to Spanish Fork (Utah) | 5,247.35 mi (8,444.79 km) |
| Villanueva de la Serena to Spanish Lake (Missouri) | 4,357.23 mi (7,012.29 km) |
| Villanueva de la Serena to Spanish Springs (Nevada) | 5,585.81 mi (8,989.50 km) |
| Villanueva de la Serena to Sparks (Nevada) | 5,591.59 mi (8,998.80 km) |
| Villanueva de la Serena to Spartanburg (South Carolina) | 4,085.74 mi (6,575.36 km) |
| Villanueva de la Serena to Spearfish (South Dakota) | 4,746.21 mi (7,638.29 km) |
| Villanueva de la Serena to Speedway (Indiana) | 4,138.16 mi (6,659.73 km) |
| Villanueva de la Serena to Spencer (Iowa) | 4,430.36 mi (7,129.97 km) |
| Villanueva de la Serena to Spokane (Washington) | 5,128.47 mi (8,253.48 km) |
| Villanueva de la Serena to Spokane Valley (Washington) | 5,121.74 mi (8,242.64 km) |
