| Villanueva de la Serena to Sangeorgiu de Mures | 1,610.67 mi (2,592.12 km) |
| Villanueva de la Serena to Sangeorz-Bai | 1,629.30 mi (2,622.11 km) |
| Villanueva de la Serena to Sannicolau Mare | 1,423.72 mi (2,291.25 km) |
| Villanueva de la Serena to Santana | 1,469.06 mi (2,364.23 km) |
| Villanueva de la Serena to Satu Mare | 1,552.99 mi (2,499.30 km) |
| Villanueva de la Serena to Scobinti | 1,733.68 mi (2,790.09 km) |
| Villanueva de la Serena to Scornicesti | 1,601.18 mi (2,576.84 km) |
| Villanueva de la Serena to Sebes | 1,562.74 mi (2,514.98 km) |
| Villanueva de la Serena to Seini | 1,570.32 mi (2,527.18 km) |
| Villanueva de la Serena to Sfantu-Gheorghe | 1,667.94 mi (2,684.30 km) |
| Villanueva de la Serena to Sibiu | 1,589.11 mi (2,557.43 km) |
| Villanueva de la Serena to Sighetu Marmatiei | 1,600.44 mi (2,575.66 km) |
| Villanueva de la Serena to Sighisoara | 1,623.01 mi (2,611.99 km) |
| Villanueva de la Serena to Simeria | 1,535.05 mi (2,470.42 km) |
| Villanueva de la Serena to Sinaia | 1,653.62 mi (2,661.24 km) |
