| Villanueva de la Serena to Spello | 1,000.48 mi (1,610.12 km) |
| Villanueva de la Serena to Spilamberto | 946.03 mi (1,522.49 km) |
| Villanueva de la Serena to Spilimbergo | 1,068.46 mi (1,719.52 km) |
| Villanueva de la Serena to Spinea | 1,020.47 mi (1,642.29 km) |
| Villanueva de la Serena to Spoleto | 998.52 mi (1,606.97 km) |
| Villanueva de la Serena to Spoltore | 1,069.07 mi (1,720.50 km) |
| Villanueva de la Serena to Spresiano | 1,031.48 mi (1,660.00 km) |
| Villanueva de la Serena to Squinzano | 1,268.05 mi (2,040.73 km) |
| Villanueva de la Serena to Statte | 1,223.00 mi (1,968.24 km) |
| Villanueva de la Serena to Stezzano | 912.44 mi (1,468.43 km) |
| Villanueva de la Serena to Strada | 942.21 mi (1,516.35 km) |
| Villanueva de la Serena to Stradella | 880.76 mi (1,417.45 km) |
| Villanueva de la Serena to Striano | 1,084.75 mi (1,745.73 km) |
| Villanueva de la Serena to Subiaco | 1,012.43 mi (1,629.35 km) |
| Villanueva de la Serena to Sulmona | 1,055.40 mi (1,698.51 km) |
