| Villanueva de la Serena to Sestu | 797.55 mi (1,283.53 km) |
| Villanueva de la Serena to Settimo Torinese | 814.49 mi (1,310.80 km) |
| Villanueva de la Serena to Seveso | 889.74 mi (1,431.89 km) |
| Villanueva de la Serena to Sezze | 1,008.33 mi (1,622.75 km) |
| Villanueva de la Serena to Siano | 1,091.42 mi (1,756.48 km) |
| Villanueva de la Serena to Siena | 938.69 mi (1,510.68 km) |
| Villanueva de la Serena to Signa | 935.19 mi (1,505.04 km) |
| Villanueva de la Serena to Silea | 1,030.48 mi (1,658.40 km) |
| Villanueva de la Serena to Silvi Paese | 1,068.64 mi (1,719.80 km) |
| Villanueva de la Serena to Sinalunga | 956.94 mi (1,540.05 km) |
| Villanueva de la Serena to Siniscola | 829.31 mi (1,334.64 km) |
| Villanueva de la Serena to Sinnai | 803.48 mi (1,293.07 km) |
| Villanueva de la Serena to Siracusa | 1,152.71 mi (1,855.11 km) |
| Villanueva de la Serena to Solaro | 886.55 mi (1,426.77 km) |
| Villanueva de la Serena to Soliera | 946.25 mi (1,522.84 km) |
