| Villanueva de la Serena to Savignano sul Rubicone | 1,002.77 mi (1,613.81 km) |
| Villanueva de la Serena to Savona | 823.07 mi (1,324.60 km) |
| Villanueva de la Serena to Scafati | 1,082.58 mi (1,742.24 km) |
| Villanueva de la Serena to Scalea | 1,152.07 mi (1,854.08 km) |
| Villanueva de la Serena to Scandiano | 931.98 mi (1,499.87 km) |
| Villanueva de la Serena to Scandicci | 938.98 mi (1,511.15 km) |
| Villanueva de la Serena to Schio | 989.50 mi (1,592.45 km) |
| Villanueva de la Serena to Sciacca | 1,028.16 mi (1,654.66 km) |
| Villanueva de la Serena to Scicli | 1,125.75 mi (1,811.71 km) |
| Villanueva de la Serena to Scordia | 1,125.73 mi (1,811.68 km) |
| Villanueva de la Serena to Scorze | 1,019.98 mi (1,641.51 km) |
| Villanueva de la Serena to Sedico | 1,033.20 mi (1,662.77 km) |
| Villanueva de la Serena to Sedriano | 877.49 mi (1,412.18 km) |
| Villanueva de la Serena to Segni | 1,006.67 mi (1,620.07 km) |
| Villanueva de la Serena to Segrate | 892.07 mi (1,435.65 km) |
