| Villanueva de la Serena to Sacile | 1,047.23 mi (1,685.35 km) |
| Villanueva de la Serena to Sala Consilina | 1,139.41 mi (1,833.70 km) |
| Villanueva de la Serena to Salemi | 1,008.64 mi (1,623.25 km) |
| Villanueva de la Serena to Salerno | 1,094.88 mi (1,762.04 km) |
| Villanueva de la Serena to Salo | 949.88 mi (1,528.69 km) |
| Villanueva de la Serena to Salsomaggiore Terme | 904.53 mi (1,455.70 km) |
| Villanueva de la Serena to Saluzzo | 787.55 mi (1,267.45 km) |
| Villanueva de la Serena to Salzano | 1,019.42 mi (1,640.60 km) |
| Villanueva de la Serena to Samarate | 873.58 mi (1,405.88 km) |
| Villanueva de la Serena to San Benedetto del Tronto | 1,060.52 mi (1,706.74 km) |
| Villanueva de la Serena to San Biagio di Callalta | 1,035.09 mi (1,665.81 km) |
| Villanueva de la Serena to San Bonifacio | 978.37 mi (1,574.54 km) |
| Villanueva de la Serena to San Casciano in Val di Pesa | 937.11 mi (1,508.13 km) |
| Villanueva de la Serena to San Cataldo | 1,076.56 mi (1,732.56 km) |
| Villanueva de la Serena to San Cesareo | 996.32 mi (1,603.42 km) |
