| Villanueva de la Serena to Orbetello | 921.07 mi (1,482.32 km) |
| Villanueva de la Serena to Oria | 1,245.94 mi (2,005.15 km) |
| Villanueva de la Serena to Oristano | 769.87 mi (1,238.99 km) |
| Villanueva de la Serena to Orta Nova | 1,144.75 mi (1,842.29 km) |
| Villanueva de la Serena to Orte | 980.42 mi (1,577.84 km) |
| Villanueva de la Serena to Ortona | 1,081.51 mi (1,740.51 km) |
| Villanueva de la Serena to Orvieto | 969.29 mi (1,559.92 km) |
| Villanueva de la Serena to Orzinuovi | 917.73 mi (1,476.94 km) |
| Villanueva de la Serena to Osimo | 1,046.77 mi (1,684.61 km) |
| Villanueva de la Serena to Ospitaletto | 928.24 mi (1,493.86 km) |
| Villanueva de la Serena to Ostuni | 1,242.65 mi (1,999.85 km) |
| Villanueva de la Serena to Ottaviano | 1,080.09 mi (1,738.24 km) |
| Villanueva de la Serena to Ovada | 839.28 mi (1,350.69 km) |
| Villanueva de la Serena to Ozieri | 793.03 mi (1,276.25 km) |
| Villanueva de la Serena to Paceco | 993.22 mi (1,598.44 km) |
