| Valley Center to Southchase (Florida) | 2,130.24 mi (3,428.29 km) |
| Valley Center to Southern Pines (North Carolina) | 2,140.52 mi (3,444.83 km) |
| Valley Center to Southfield (Michigan) | 1,934.07 mi (3,112.58 km) |
| Valley Center to Southgate (Michigan) | 1,934.32 mi (3,112.98 km) |
| Valley Center to Southlake (Texas) | 1,148.34 mi (1,848.07 km) |
| Valley Center to Spanaway (Washington) | 998.98 mi (1,607.70 km) |
| Valley Center to Spanish Fork (Utah) | 560.54 mi (902.11 km) |
| Valley Center to Spanish Lake (Missouri) | 1,540.58 mi (2,479.32 km) |
| Valley Center to Spanish Springs (Nevada) | 467.64 mi (752.59 km) |
| Valley Center to Sparks (Nevada) | 463.05 mi (745.20 km) |
| Valley Center to Spartanburg (South Carolina) | 2,001.14 mi (3,220.53 km) |
| Valley Center to Spearfish (South Dakota) | 1,050.58 mi (1,690.75 km) |
| Valley Center to Speedway (Indiana) | 1,758.14 mi (2,829.45 km) |
| Valley Center to Spencer (Iowa) | 1,364.58 mi (2,196.08 km) |
| Valley Center to Spokane (Washington) | 997.54 mi (1,605.38 km) |
