| Upton to Southern Pines (North Carolina) | 3,778.74 mi (6,081.29 km) |
| Upton to Southfield (Michigan) | 3,585.15 mi (5,769.73 km) |
| Upton to Southgate (Michigan) | 3,595.56 mi (5,786.50 km) |
| Upton to Southlake (Texas) | 4,583.82 mi (7,376.95 km) |
| Upton to Spanaway (Washington) | 4,636.20 mi (7,461.25 km) |
| Upton to Spanish Fork (Utah) | 4,709.18 mi (7,578.70 km) |
| Upton to Spanish Lake (Missouri) | 4,024.40 mi (6,476.65 km) |
| Upton to Spanish Springs (Nevada) | 4,983.71 mi (8,020.50 km) |
| Upton to Sparks (Nevada) | 4,989.86 mi (8,030.40 km) |
| Upton to Spartanburg (South Carolina) | 3,891.64 mi (6,262.98 km) |
| Upton to Spearfish (South Dakota) | 4,221.14 mi (6,793.26 km) |
| Upton to Speedway (Indiana) | 3,825.15 mi (6,155.98 km) |
| Upton to Spencer (Iowa) | 3,991.53 mi (6,423.75 km) |
| Upton to Spokane (Washington) | 4,468.15 mi (7,190.80 km) |
| Upton to Spokane Valley (Washington) | 4,462.85 mi (7,182.26 km) |
