| Two Rivers to Sunset (Florida) | 1,337.60 mi (2,152.65 km) |
| Two Rivers to Superior (Colorado) | 945.67 mi (1,521.91 km) |
| Two Rivers to Superior (Wisconsin) | 279.84 mi (450.37 km) |
| Two Rivers to Surprise (Arizona) | 1,511.67 mi (2,432.80 km) |
| Two Rivers to Susanville (California) | 1,696.25 mi (2,729.85 km) |
| Two Rivers to Sussex (Wisconsin) | 77.52 mi (124.76 km) |
| Two Rivers to Suwanee (Georgia) | 723.01 mi (1,163.58 km) |
| Two Rivers to Swansea (Illinois) | 406.84 mi (654.74 km) |
| Two Rivers to Sweetwater (Florida) | 1,332.39 mi (2,144.27 km) |
| Two Rivers to Sweetwater (Texas) | 1,063.03 mi (1,710.78 km) |
| Two Rivers to Sycamore (Illinois) | 159.27 mi (256.33 km) |
| Two Rivers to Sylacauga (Alabama) | 761.86 mi (1,226.09 km) |
| Two Rivers to Sylvania (Ohio) | 258.72 mi (416.37 km) |
| Two Rivers to Syosset (New York) | 752.52 mi (1,211.06 km) |
| Two Rivers to Syracuse (New York) | 577.04 mi (928.66 km) |
