| Two Rivers to Southchase (Florida) | 1,142.49 mi (1,838.66 km) |
| Two Rivers to Southern Pines (North Carolina) | 755.93 mi (1,216.55 km) |
| Two Rivers to Southfield (Michigan) | 246.28 mi (396.35 km) |
| Two Rivers to Southgate (Michigan) | 258.42 mi (415.89 km) |
| Two Rivers to Southlake (Texas) | 929.29 mi (1,495.55 km) |
| Two Rivers to Spanaway (Washington) | 1,681.56 mi (2,706.21 km) |
| Two Rivers to Spanish Fork (Utah) | 1,259.14 mi (2,026.38 km) |
| Two Rivers to Spanish Lake (Missouri) | 394.96 mi (635.62 km) |
| Two Rivers to Spanish Springs (Nevada) | 1,667.97 mi (2,684.33 km) |
| Two Rivers to Sparks (Nevada) | 1,672.38 mi (2,691.43 km) |
| Two Rivers to Spartanburg (South Carolina) | 703.81 mi (1,132.68 km) |
| Two Rivers to Spearfish (South Dakota) | 801.41 mi (1,289.74 km) |
| Two Rivers to Speedway (Indiana) | 309.12 mi (497.48 km) |
| Two Rivers to Spencer (Iowa) | 384.72 mi (619.15 km) |
| Two Rivers to Spokane (Washington) | 1,446.07 mi (2,327.23 km) |
