| Two Rivers to Scottsbluff (Nebraska) | 826.17 mi (1,329.59 km) |
| Two Rivers to Scottsboro (Alabama) | 662.31 mi (1,065.88 km) |
| Two Rivers to Scottsdale (Arizona) | 1,484.21 mi (2,388.61 km) |
| Two Rivers to Scranton (Pennsylvania) | 632.89 mi (1,018.54 km) |
| Two Rivers to Seabrook (Maryland) | 659.24 mi (1,060.94 km) |
| Two Rivers to Seabrook (Texas) | 1,087.04 mi (1,749.42 km) |
| Two Rivers to Seaford (New York) | 756.96 mi (1,218.22 km) |
| Two Rivers to Seagoville (Texas) | 929.94 mi (1,496.59 km) |
| Two Rivers to Seal Beach (California) | 1,775.63 mi (2,857.61 km) |
| Two Rivers to Searcy (Arkansas) | 654.08 mi (1,052.63 km) |
| Two Rivers to Seaside (California) | 1,860.45 mi (2,994.11 km) |
| Two Rivers to SeaTac (Washington) | 1,673.42 mi (2,693.12 km) |
| Two Rivers to Seattle (Washington) | 1,673.57 mi (2,693.35 km) |
| Two Rivers to Sebastian (Florida) | 1,197.82 mi (1,927.70 km) |
| Two Rivers to Sebring (Florida) | 1,201.61 mi (1,933.81 km) |
