| Twinsburg to Southchase (Florida) | 894.26 mi (1,439.17 km) |
| Twinsburg to Southern Pines (North Carolina) | 437.70 mi (704.40 km) |
| Twinsburg to Southfield (Michigan) | 122.79 mi (197.62 km) |
| Twinsburg to Southgate (Michigan) | 109.32 mi (175.94 km) |
| Twinsburg to Southlake (Texas) | 1,037.88 mi (1,670.31 km) |
| Twinsburg to Spanaway (Washington) | 2,043.95 mi (3,289.42 km) |
| Twinsburg to Spanish Fork (Utah) | 1,575.55 mi (2,535.59 km) |
| Twinsburg to Spanish Lake (Missouri) | 495.09 mi (796.77 km) |
| Twinsburg to Spanish Springs (Nevada) | 1,995.60 mi (3,211.60 km) |
| Twinsburg to Sparks (Nevada) | 1,999.56 mi (3,217.99 km) |
| Twinsburg to Spartanburg (South Carolina) | 441.43 mi (710.42 km) |
| Twinsburg to Spearfish (South Dakota) | 1,149.30 mi (1,849.63 km) |
| Twinsburg to Speedway (Indiana) | 273.30 mi (439.83 km) |
| Twinsburg to Spencer (Iowa) | 711.67 mi (1,145.32 km) |
| Twinsburg to Spokane (Washington) | 1,809.46 mi (2,912.05 km) |
